Molecular weight (DA)
20kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human ADM. AA range:101-150
Specificity
ADM Polyclonal Antibody detects endogenous levels of ADM protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014],
Function
function:AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.,similarity:Belongs to the adrenomedullin family.,tissue specificity:Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.,
Fields
>>Neuroactive ligand-receptor interaction;>>Vascular smooth muscle contraction
Human protein sequence Database
P35318
Mouse protein sequence database
P97297
Rat protein sequence database
P43145
Cellular localization
Secreted.
Tissue expression
Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues.
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