Molecular weight (DA)
20kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human BTC. AA range:21-70
Specificity
Probetacellulin Polyclonal Antibody detects endogenous levels of Probetacellulin protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015],
Function
disease:Betacellulin from beta cells could play a role in the vascular complications associated with diabetes.,function:Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. The effects of betacellulin are probably mediated by the EGF receptor and other related receptors.,similarity:Contains 1 EGF-like domain.,subunit:Monomer.,tissue specificity:Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.,
Protein name
Probetacellulin
Abbreviation
Probetacellulin
Other name
BTC; Probetacellulin
Fields
>>ErbB signaling pathway
Human protein sequence Database
P35070
Mouse protein sequence database
Q05928
Rat protein sequence database
Cellular localization
[Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein.
Tissue expression
Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine.
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