Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human BMP6. AA range:341-390
Specificity
BMP-6 Polyclonal Antibody detects endogenous levels of BMP-6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016],
Function
function:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 6 entry,similarity:Belongs to the TGF-beta family.,subunit:Interacts with SOSTDC1.,
Protein name
Bone morphogenetic protein 6
Other name
BMP6; VGR; Bone morphogenetic protein 6; BMP-6; VG-1-related protein; VG-1-R; VGR-1
Fields
>>Cytokine-cytokine receptor interaction;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Ovarian steroidogenesis
Human protein sequence Database
P22004
Mouse protein sequence database
P20722
Rat protein sequence database
Q04906
Cellular localization
Secreted .
Tissue expression
Bone,PCR rescued clones,
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