Molecular weight (DA)
55kD
Immunogen
The antiserum was produced against synthesized peptide derived from human TISD. AA range:207-256
Specificity
TIS11D Polyclonal Antibody detects endogenous levels of TIS11D protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008],
Function
function:Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation.,similarity:Contains 2 C3H1-type zinc fingers.,
Protein name
Zinc finger protein 36 C3H1 type-like 2
Other name
ZFP36L2; BRF2; ERF2; RNF162C; TIS11D; Zinc finger protein 36; C3H1 type-like 2; ZFP36-like 2; Butyrate response factor 2; EGF-response factor 2; ERF-2; Protein TIS11D
Fields
>>Cellular senescence
Human protein sequence Database
P47974
Mouse protein sequence database
P23949
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner. .
Tissue expression
Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009).
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