Molecular weight (DA)
17kD
Immunogen
Synthesized peptide derived from Interleukin-1 family member 10 at AA range: 101-150
Specificity
IL-1F10 Polyclonal Antibody detects endogenous levels of IL-1F10 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008],
Function
function:Binds soluble IL-1 receptor type 1.,online information:Interleukin-1 entry,similarity:Belongs to the IL-1 family.,tissue specificity:Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.,
Protein name
Interleukin-1 family member 10
Other name
IL1F10; FIL1T; IL1HY2; FKSG75; Interleukin-1 family member 10; IL-1F10; FIL1 theta; Interleukin-1 HY2; IL-1HY2; Interleukin-1 theta; IL-1 theta
Fields
>>Cytokine-cytokine receptor interaction
Human protein sequence Database
Q8WWZ1
Mouse protein sequence database
Q8R459
Rat protein sequence database
Cellular localization
Cytoplasm . Secreted . The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. .
Tissue expression
Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
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