Immunogen
Synthetic peptide from human protein at AA range: 100-144
Specificity
The antibody detects endogenous GM-CSF
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. [provided by RefSeq, Jul 2008],
Function
function:Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.,online information:Clinical information on Leukine,pharmaceutical:Available under the names Leukine (Immunex) and Leucomax (Novartis). Used in myeloid reconstitution following bone marrow transplant, bone marrow transplant engraftment failure or delay, mobilization and following transplantation of autologous peripheral blood progenitor cells, and following induction chemotherapy in older adults with acute myelogenous leukemia.,polymorphism:Variant Ile-117 may be a risk factor for atopic asthma.,similarity:Belongs to the GM-CSF family.,subunit:Monomer.,
Protein name
Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Colony-stimulating factor) (CSF) (Molgramostin) (Sargramostim)
Other name
Granulocyte-macrophage colony-stimulating factor (GM-CSF;Colony-stimulating factor;CSF;Molgramostin;Sargramostim)
Fields
>>Cytokine-cytokine receptor interaction;>>JAK-STAT signaling pathway;>>Hematopoietic cell lineage;>>Natural killer cell mediated cytotoxicity;>>IL-17 signaling pathway;>>T cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>TNF signaling pathway;>>Shigellosis;>>Amoebiasis;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Coronavirus disease - COVID-19;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia;>>Rheumatoid arthritis
Human protein sequence Database
P04141
Mouse protein sequence database
P01587
Rat protein sequence database
Cellular localization
Secreted .
Tissue expression
Peripheral blood,
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