Molecular weight (DA)
152kD
Immunogen
The antiserum was produced against synthesized peptide derived from human ARHGEF10. AA range:339-388
Specificity
ARHGEF10 Polyclonal Antibody detects endogenous levels of ARHGEF10 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],
Function
disease:Defects in ARHGEF10 are the cause of slowed nerve conduction velocity (SNCV) [MIM:608236]. Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant.,function:May play a role in developmental myelination of peripheral nerves.,sequence caution:Cloning artifact.,sequence caution:Translated as Lys.,similarity:Contains 1 DH (DBL-homology) domain.,
Protein name
Rho guanine nucleotide exchange factor 10
Other name
ARHGEF10; KIAA0294; Rho guanine nucleotide exchange factor 10
Human protein sequence Database
O15013
Mouse protein sequence database
Q8C033
Rat protein sequence database
Cellular localization
centrosome,cytosol,
Tissue expression
Amygdala,Brain,Duodenum,Prostate,Testis,Uterus,
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