Molecular weight (DA)
41kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GNAI3. AA range:31-80
Specificity
Gα i-3 Polyclonal Antibody detects endogenous levels of Gα i-3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled endothelin receptor pathway. [provided by RefSeq, Jun 2012],
Function
function:Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K(+) channels.,similarity:Belongs to the G-alpha family. G(i/o/t/z) subfamily.,subunit:G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1.,
Protein name
Guanine nucleotide-binding protein G(k) subunit alpha
Other name
GNAI3; Guanine nucleotide-binding protein G(k) subunit alpha; G(i) alpha-3
Fields
>>Rap1 signaling pathway;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>Sphingolipid signaling pathway;>>Adrenergic signaling in cardiomyocytes;>>Axon guidance;>>Apelin signaling pathway;>>Gap junction;>>Platelet activation;>>Leukocyte transendothelial migration;>>Circadian entrainment;>>Retrograde endocannabinoid signaling;>>Glutamatergic synapse;>>Cholinergic synapse;>>Serotonergic synapse;>>GABAergic synapse;>>Dopaminergic synapse;>>Long-term depression;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Melanogenesis;>>Oxytocin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Renin secretion;>>Relaxin signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Cushing syndrome;>>Growth hormone synthesis, secretion and action;>>Gastric acid secretion;>>Parkinson disease;>>Cocaine addiction;>>Morphine addiction;>>Alcoholism;>>Pertussis;>>Chagas disease;>>Toxoplasmosis;>>Human cytomegalovirus infectio
Human protein sequence Database
P08754
Mouse protein sequence database
Q9DC51
Rat protein sequence database
P08753
Cellular localization
Cytoplasm . Cell membrane ; Lipid-anchor . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. .
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