Immunogen
Synthesized peptide derived from Rag B . at AA range: 50-130
Specificity
Rag B Polyclonal Antibody detects endogenous levels of Rag B protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008],
Function
function:Involved in the RCC1/Ran-GTPase pathway. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.,similarity:Belongs to the GTR/RAG GTP-binding protein family.,subunit:The short isoform binds GTP (By similarity). Interacts with RRAGC and RRAGD.,
Protein name
Ras-related GTP-binding protein B
Other name
RRAGB; Ras-related GTP-binding protein B; Rag B; RagB
Fields
>>Autophagy - animal;>>mTOR signaling pathway;>>Shigellosis
Human protein sequence Database
Q5VZM2
Mouse protein sequence database
Q6NTA4
Rat protein sequence database
Q63487
Cellular localization
Cytoplasm . Lysosome .
Tissue expression
Adipose tissue,Brain,Skin,
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