Molecular weight (DA)
50kD
Immunogen
Synthesized peptide derived from the C-terminal region of human GDI-2.
Specificity
GDI-2 Polyclonal Antibody detects endogenous levels of GDI-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],
Function
function:Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.,similarity:Belongs to the Rab GDI family.,tissue specificity:Ubiquitous.,
Protein name
Rab GDP dissociation inhibitor beta
Other name
GDI2; RABGDIB; Rab GDP dissociation inhibitor beta; Rab GDI beta; Guanosine diphosphate dissociation inhibitor 2; GDI-2
Human protein sequence Database
P50395
Mouse protein sequence database
Q61598
Rat protein sequence database
P50399
Cellular localization
Cytoplasm . Membrane ; Peripheral membrane protein .
Tissue expression
Ubiquitous.
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