Molecular weight (DA)
54kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GABRG1. AA range:11-60
Specificity
GABAA Rγ1 Polyclonal Antibody detects endogenous levels of GABAA Rγ1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008],
Function
function:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.,miscellaneous:This subunit carries the benzodiazepine binding site.,online information:Forbidden fruit - Issue 56 of March 2005,PTM:May be palmitoylated.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.,
Protein name
Gamma-aminobutyric acid receptor subunit gamma-1
Other name
GABRG1; Gamma-aminobutyric acid receptor subunit gamma-1; GABA(A) receptor subunit gamma-1
Fields
>>Neuroactive ligand-receptor interaction;>>Retrograde endocannabinoid signaling;>>GABAergic synapse;>>Morphine addiction;>>Nicotine addiction
Human protein sequence Database
Q8N1C3
Mouse protein sequence database
Q9R0Y8
Rat protein sequence database
P23574
Cellular localization
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue expression
Amygdala,Brain,
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