Molecular weight (DA)
51kD
Immunogen
The antiserum was produced against synthesized peptide derived from human KCNG2. AA range:321-370
Specificity
KCNG2 Polyclonal Antibody detects endogenous levels of KCNG2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit of the voltage-gated potassium channel. The delayed-rectifier type channels containing this subunit may contribute to cardiac action potential repolarization. [provided by RefSeq, Jul 2008],
Function
domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.,miscellaneous:Heterodimers with KCNB1 are highly sensitive to inhibition by tetraethylammonium (TEA) and propafenone.,similarity:Belongs to the potassium channel family. G subfamily.,subunit:Heterodimer with KCNB1. Does not form homomultimers.,tissue specificity:Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.,
Protein name
Potassium voltage-gated channel subfamily G member 2
Other name
KCNG2; KCNF2; Potassium voltage-gated channel subfamily G member 2; Cardiac potassium channel subunit; Voltage-gated potassium channel subunit Kv6.2
Human protein sequence Database
Q9UJ96
Mouse protein sequence database
Rat protein sequence database
Q9QYU3
Cellular localization
Membrane; Multi-pass membrane protein.
Tissue expression
Highly expressed in heart, liver, skeletal muscle, kidney and pancreas. Detected at low levels in brain, lung and placenta.
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