Molecular weight (DA)
44kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human P2RX3. AA range:81-130
Specificity
P2X3 Polyclonal Antibody detects endogenous levels of P2X3 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008],
Function
function:Receptor for ATP that acts as a ligand gated ion channel.,online information:P2X receptor entry,similarity:Belongs to the P2X receptor family.,subunit:Homo- or heteropolymers.,
Protein name
P2X purinoceptor 3
Other name
P2RX3; P2X purinoceptor 3; P2X3; ATP receptor; Purinergic receptor
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Taste transduction
Human protein sequence Database
P56373
Mouse protein sequence database
Q3UR32
Rat protein sequence database
P49654
Cellular localization
Cell membrane ; Multi-pass membrane protein .
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