Immunogen
The antiserum was produced against synthesized peptide derived from human CDC5L. AA range:721-770
Specificity
Cdc5L Polyclonal Antibody detects endogenous levels of Cdc5L protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008],
Function
disease:A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.,function:DNA-binding protein involved in cell cycle control. May act as a transcription activator. Also seems to be involved in the second catalytic step of pre-mRNA splicing.,PTM:Phosphorylated; which enhances interaction with PPP1R8.,similarity:Belongs to the CEF1 family.,similarity:Contains 2 HTH myb-type DNA-binding domains.,subcellular location:May shuttle between cytoplasm and nucleus.,subunit:Homodimer. Interacts with DAPK3 (By similarity). Binds to DNA. Binds to adeno-pre-mRNA in an ATP-stimulated manner. Belongs to the spliceosome complex. Part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Identified in the spliceosome C complex, at least composed
Protein name
Cell division cycle 5-like protein
Other name
CDC5L; KIAA0432; PCDC5RP; Cell division cycle 5-like protein; Cdc5-like protein; Pombe cdc5-related protein
Human protein sequence Database
Q99459
Mouse protein sequence database
Q6A068
Rat protein sequence database
O08837
Cellular localization
Nucleus . Nucleus speckle . Cytoplasm . May shuttle between cytoplasm and nucleus. .
Tissue expression
Ubiquitously expressed in both fetal and adult tissues.
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