Molecular weight (DA)
60kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CDC6. AA range:491-540
Specificity
Cdc6 Polyclonal Antibody detects endogenous levels of Cdc6 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008],
Function
function:Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.,similarity:Belongs to the CDC6/cdc18 family.,subcellular location:The protein is nuclear in G1 and cytoplasmic in S-phase cells.,subunit:Interacts with PCNA, ORC1L, cyclin-CDK and HUWE1.,
Protein name
Cell division control protein 6 homolog
Other name
CDC6; CDC18L; Cell division control protein 6 homolog; CDC6-related protein; Cdc18-related protein; HsCdc18; p62(cdc6); HsCDC6
Fields
>>Cell cycle;>>Chemical carcinogenesis - receptor activation
Human protein sequence Database
Q99741
Mouse protein sequence database
O89033
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm . The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895). .
Tissue expression
Brain,Epithelium,
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