Molecular weight (DA)
70kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CDC7. AA range:1-50
Specificity
Cdc7 Polyclonal Antibody detects endogenous levels of Cdc7 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008],
Function
alternative products:A number of isoforms may be produced,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,function:Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.,
Protein name
Cell division cycle 7-related protein kinase
Other name
CDC7; CDC7L1; Cell division cycle 7-related protein kinase; CDC7-related kinase; HsCdc7; huCdc7
Human protein sequence Database
O00311
Mouse protein sequence database
Q9Z0H0
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Brain,Embryonal rhabdomyosarcoma,Liver,Testis,
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