Molecular weight (DA)
29kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Cyclin G. AA range:161-210
Specificity
Cyclin G Polyclonal Antibody detects endogenous levels of Cyclin G protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008],
Function
developmental stage:Very low levels in normal cells during G1 phase, which increase as cells enter the S phase and stay high throughout the S and G2/M phases. In breast cancer cells consistent high levels are found throughout the cell cycle.,function:May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.,induction:Activated in breast and prostate cancer cells. Activated by actinomycin-D induced DNA damage.,similarity:Belongs to the cyclin family. Cyclin G subfamily.,subcellular location:DNA replication foci after DNA damage.,tissue specificity:High levels in skeletal muscle, ovary, kidney and colon.,
Other name
CCNG1; CCNG; CYCG1; Cyclin-G1; Cyclin-G
Fields
>>p53 signaling pathway;>>MicroRNAs in cancer
Human protein sequence Database
P51959
Mouse protein sequence database
P51945
Rat protein sequence database
P39950
Cellular localization
Nucleus . DNA replication foci after DNA damage.
Tissue expression
High levels in skeletal muscle, ovary, kidney and colon.
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