Molecular weight (DA)
56kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CDKL2. AA range:211-260
Specificity
KKIAMRE Polyclonal Antibody detects endogenous levels of KKIAMRE protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The [NKR]KIAxRE motif seems to be a cyclin-binding region.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in testis and kidney, and at lower level in brain and lung.,
Protein name
Cyclin-dependent kinase-like 2
Other name
CDKL2; Cyclin-dependent kinase-like 2; Protein kinase p56 KKIAMRE; Serine/threonine-protein kinase KKIAMRE
Human protein sequence Database
Q92772
Mouse protein sequence database
Q9QUK0
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus .
Tissue expression
Expressed in testis and kidney, and at lower level in brain and lung.
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