Molecular weight (DA)
67kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CDKL3. AA range:291-340
Specificity
NKIAMRE Polyclonal Antibody detects endogenous levels of NKIAMRE protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a member of cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This gene was identified as a gene absent in leukemic patients with chromosome 5q deletion. This loss may be an important determinant of dysmyelopoiesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008],
Function
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,domain:The [NKR]KIAxRE motif seems to be a cyclin-binding region.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,
Protein name
Cyclin-dependent kinase-like 3
Other name
CDKL3; NKIAMRE; Cyclin-dependent kinase-like 3; Serine/threonine-protein kinase NKIAMRE
Human protein sequence Database
Q8IVW4
Mouse protein sequence database
Q8BLF2
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Fetal heart,Testis,
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