Immunogen
The antiserum was produced against synthesized peptide derived from human NPY. AA range:45-94
Specificity
NPY Polyclonal Antibody detects endogenous levels of NPY protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:100-500，WB 1:500-2000,ELISA 1:5000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014],
Function
function:NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone.,online information:Neuropeptide Y entry,similarity:Belongs to the NPY family.,tissue specificity:One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.,
Protein name
Pro-neuropeptide Y
Other name
NPY; Pro-neuropeptide Y
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Adipocytokine signaling pathway;>>Regulation of lipolysis in adipocytes;>>Alcoholism
Human protein sequence Database
P01303
Mouse protein sequence database
P57774
Rat protein sequence database
P07808
Cellular localization
Secreted. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle .
Tissue expression
One of the most abundant peptides in the nervous system. Also found in some chromaffin cells of the adrenal medulla.
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