Molecular weight (DA)
175kD
Immunogen
Synthesized peptide derived from the Internal region of human SCP-2.
Specificity
SCP-2 Polyclonal Antibody detects endogenous levels of SCP-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq, Jul 2008],
Function
function:Major component of the axial/lateral elements of synaptonemal complexes (SCS) during meiotic prophase. May be involved in the organization of chromatin by temporarily binding to DNA scaffold attachment regions. Requires SYCP3, but not SYCP1, in order to be incorporated into the axial/lateral elements.,similarity:Belongs to the SYCP2 family.,subcellular location:In axial/lateral elements of the tripartite segments of synaptonemal complexes.,subunit:Heterodimer with SYCP3. Interacts with SYCP3, SMC1A and SMC3.,
Protein name
Synaptonemal complex protein 2
Other name
SYCP2; SCP2; Synaptonemal complex protein 2; SCP-2; Synaptonemal complex lateral element protein; hsSCP2
Human protein sequence Database
Q9BX26
Mouse protein sequence database
Q9CUU3
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . In axial/lateral elements of the tripartite segments of synaptonemal complexes. .
Tissue expression
Kidney,Testis,
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