Molecular weight (DA)
84kD
Immunogen
The antiserum was produced against synthesized peptide derived from human CDH22. AA range:111-160
Specificity
Cadherin-22 Polyclonal Antibody detects endogenous levels of Cadherin-22 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the cadherin superfamily. The gene product is composed of five cadherin repeat domains and a cytoplasmic tail similar to the highly conserved cytoplasmic region of classical cadherins. Expressed predominantly in the brain, this putative calcium-dependent cell adhesion protein may play an important role in morphogenesis and tissue formation in neural and non-neural cells during development and maintenance of the brain and neuroendocrine organs. [provided by RefSeq, Jul 2008],
Function
function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues.,similarity:Contains 5 cadherin domains.,
Other name
CDH22; C20orf25; Cadherin-22; Pituitary and brain cadherin; PB-cadherin
Human protein sequence Database
Q9UJ99
Mouse protein sequence database
Q9WTP5
Rat protein sequence database
Q63315
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
Tissue expression
Brain,Testis,
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