Molecular weight (DA)
37kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GJA4. AA range:81-130
Specificity
Connexin 37 Polyclonal Antibody detects endogenous levels of Connexin 37 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction. [provided by RefSeq, Jul 2008],
Function
function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.,similarity:Belongs to the connexin family.,similarity:Belongs to the connexin family. Alpha-type (group II) subfamily.,subunit:A connexon is composed of a hexamer of connexins.,tissue specificity:Expressed in multiple organs and tissues, including heart, uterus, ovary, and blood vessel endothelium.,
Protein name
Gap junction alpha-4 protein
Other name
GJA4; Gap junction alpha-4 protein; Connexin-37; Cx37
Human protein sequence Database
P35212
Mouse protein sequence database
P28235
Rat protein sequence database
Q03190
Cellular localization
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Tissue expression
Expressed in multiple organs and tissues, including heart, uterus, ovary, and blood vessel endothelium.
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