Molecular weight (DA)
45kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GJC1. AA range:231-280
Specificity
Connexin 45 Polyclonal Antibody detects endogenous levels of Connexin 45 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008],
Function
function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.,similarity:Belongs to the connexin family. Gamma-type subfamily.,subunit:A connexon is composed of a hexamer of connexins.,
Protein name
Gap junction gamma-1 protein
Other name
GJC1; GJA7; Gap junction gamma-1 protein; Connexin-45; Cx45; Gap junction alpha-7 protein
Human protein sequence Database
P36383
Mouse protein sequence database
P28229
Rat protein sequence database
A4GG66
Cellular localization
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Tissue expression
Testis,Uterus,
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