Molecular weight (DA)
39kD
Immunogen
The antiserum was produced against synthesized peptide derived from the N-terminal region of human GJA5. AA range:21-70
Specificity
Connexin-40 Polyclonal Antibody detects endogenous levels of Connexin-40 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008],
Function
disease:Defects in GJA5 are a cause of idiopathic atrial fibrillation [MIM:108770]. Atrial fibrillation (AF) is the most common cardiac arrhythmia and is characterized by rapid and irregular activation of the atrium.,function:One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.,similarity:Belongs to the connexin family. Alpha-type (group II) subfamily.,subunit:A connexon is composed of a hexamer of connexins.,
Protein name
Gap junction alpha-5 protein
Other name
GJA5; Gap junction alpha-5 protein; Connexin-40; Cx40
Human protein sequence Database
P36382
Mouse protein sequence database
Q01231
Rat protein sequence database
P28234
Cellular localization
Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
Tissue expression
Placenta,
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