Immunogen
Synthesized peptide derived from human C-ternal CTR2
Specificity
This antibody detects endogenous levels of CTR2 at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) . May play a role in classical or alternative activation of macrophages via its role in arginine transport.
Gene Name
SLC7A2 ATRC2 CAT2
Protein name
Low affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (Solute carrier family 7 member 2)
Other name
Low affinity cationic amino acid transporter 2 (CAT-2) (CAT2) (Solute carrier family 7 member 2)
Human protein sequence Database
P52569
Mouse protein sequence database
P18581
Rat protein sequence database
B5D5N9
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Expressed at high levels in the skeletal muscle, placenta and ovary. Expressed at intermediate levels in the liver and pancreas and at low levels in the kidney and heart.
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