Molecular weight (DA)
100kD
Immunogen
Synthesized peptide derived from human GAB2 (Phospho Tyr614)
Specificity
This antibody detects endogenous levels of GAB2 (Phospho Tyr614) Rabbit pAb at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
GRB2 associated binding protein 2(GAB2) Homo sapiens This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009],
Function
PTM:Dephosphorylated by PTPN11.,PTM:Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R.,similarity:Belongs to the GAB family.,similarity:Contains 1 PH domain.,subunit:Interacts with GRB2, PI-3 kinase and with other SH2-containing proteins.,
Protein name
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Other name
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Fields
>>Ras signaling pathway;>>Sphingolipid signaling pathway;>>Phospholipase D signaling pathway;>>Osteoclast differentiation;>>Fc epsilon RI signaling pathway;>>Fc gamma R-mediated phagocytosis;>>Chronic myeloid leukemia
Human protein sequence Database
Q9UQC2
Mouse protein sequence database
Q9Z1S8
Rat protein sequence database
Q9EQH1
Cellular localization
Cytoplasm . Cell membrane .
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