Molecular weight (DA)
28kD
Immunogen
Synthesized peptide derived from human 14-3-3 eta
Specificity
This antibody detects endogenous levels of 14-3-3 eta at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Function
function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.,similarity:Belongs to the 14-3-3 family.,subunit:Homodimer (By similarity). Interacts with many nuclear hormone receptors and cofactors including AR, ESR1, ESR2, MC2R, NR3C1, NRIP1, PPARBP and THRA. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with RGNEF and PCTK1 (By similarity). Weakly interacts with CDKN1B.,tissue specificity:Expressed mainly in the brain and present in other tissues albeit at lower levels.,
Abbreviation
PI3 Kinase P85α
Other name
14-3-3 protein eta (Protein AS1)
Human protein sequence Database
Q04917
Mouse protein sequence database
P68510
Rat protein sequence database
P68511
Tissue expression
Expressed mainly in the brain and present in other tissues albeit at lower levels.
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