Immunogen
Synthesized peptide derived from human C-ternal REEP5
Specificity
This antibody detects endogenous levels of REEP5 at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
Plays an essential role in heart function and development by regulating the organization and function of the sarcoplasmic reticulum in cardiomyocytes.
Gene Name
REEP5 C5orf18 DP1 TB2
Protein name
Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2)
Other name
Receptor expression-enhancing protein 5 (Polyposis locus protein 1) (Protein TB2)
Human protein sequence Database
Q00765
Mouse protein sequence database
Q60870
Rat protein sequence database
B2RZ37
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Sarcoplasmic reticulum membrane ; Multi-pass membrane protein . Localizes to endoplasmic reticulum tubular network (PubMed:23969831). In cardiomyocytes, localizes to the junctional sarcoplasmic reticulum membrane which is closely tethered to the cell membrane and contractile machinery (By similarity). .
Tissue expression
Expressed in heart (at protein level) (PubMed:32075961). Expressed in circumvallate papillae and testis (PubMed:16720576).
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