Immunogen
Synthesized peptide derived from human N-ternal SIPA1
Specificity
This antibody detects endogenous levels of SIPA1 at Human, Mouse
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 in vitro, converting them to the putatively inactive GDP-bound state . Affects cell cycle progression (By similarity).
Protein name
Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1)
Other name
Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1)
Human protein sequence Database
Q96FS4
Mouse protein sequence database
P46062
Rat protein sequence database
Cellular localization
Nucleus . Cytoplasm, perinuclear region . Endomembrane system; Peripheral membrane protein . Mostly localized in the perinuclear membraneous region. .
Tissue expression
Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord.
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