Immunogen
Synthesized peptide derived from human DUX3 AA range: 27-77
Specificity
This antibody detects endogenous levels of DUX3 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX3, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 606009).[supplied by OMIM, Mar 2008],
Function
developmental stage:Expressed in fetal tissue.,miscellaneous:DUX genes are present in 3.3-kilobase elements, a tandem repeat family scattered in the genome found on the short arms of all acrocentric chromosomes as well as on several other chromosomes. May be functional despite lack of introns and of a poly(A) addition signal.,similarity:Belongs to the paired homeobox family.,similarity:Contains 2 homeobox DNA-binding domains.,tissue specificity:Expressed in hepatoma Hep3B cells.,
Human protein sequence Database
Q96PT4
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in hepatoma Hep3B cells.