Immunogen
Synthesized peptide derived from human C-ternal PHF8
Specificity
This antibody detects endogenous levels of PHF8 at Human, Mouse
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 IHC 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity
Gene Name
PHF8 KIAA1111 ZNF422
Protein name
Histone lysine demethylase PHF8 (EC 1.14.11.27) (PHD finger protein 8)
Other name
Histone lysine demethylase PHF8 (EC 1.14.11.27) (PHD finger protein 8)
Human protein sequence Database
Q9UPP1
Mouse protein sequence database
Q80TJ7
Rat protein sequence database
Cellular localization
Nucleus . Nucleus, nucleolus . Recruited to H3K4me3 sites on chromatin during interphase (PubMed:20622854). Dissociates from chromatin when cells enter mitosis (PubMed:20622854). .
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车