Molecular weight (DA)
Molecular Weight
Calculated MW: 28 kDa; Observed MW: 28 kDa
Immunogen
Recombinant fusion protein containing a sequence of human NR0B2 (NP_068804.1).
Dilution rate
WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Purification process (Immunogen)
Background
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
Other name
NR0B2; SHP; SHP1; nuclear receptor subfamily 0 group B member 2
Human gene ID
SwissProt ID
Q15466
Human protein sequence Database
Gene ID
8431
Mouse protein sequence database
Rat protein sequence database
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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