Molecular weight (DA)
41kD
Immunogen
Synthesized peptide derived from human DMRT1. AA range:330-373
Specificity
This antibody detects endogenous levels of DMRT1 at Human, Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play
Protein name
Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1)
Human protein sequence Database
Q9Y5R6
Mouse protein sequence database
Q9QZ59
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Testis-specific. Expressed in prostate cancer (at protein level).
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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