Molecular weight (DA)
44kD
Immunogen
Synthesized peptide derived from human CREST
Specificity
This antibody detects endogenous levels of CREST at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves
Gene Name
SS18L1 CREST KIAA0693
Protein name
Calcium-responsive transactivator (SS18-like protein 1) (SYT homolog 1)
Human protein sequence Database
O75177
Mouse protein sequence database
Q8BW22
Rat protein sequence database
Q91XJ0
Cellular localization
Nucleus . Chromosome, centromere, kinetochore . Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). .
Tissue expression
Ubiquitous; with lowest levels in spleen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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