Molecular weight (DA)
131kD
Immunogen
Synthesized peptide derived from human WAPL; WAPAL
Specificity
This antibody detects endogenous levels of WAPL; WAPAL at Human, Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Regulator of sister chromatid cohesion in mitosis which negatively regulates cohesin association with chromatin. Involved in both sister chromatid cohesion during interphase and sister-chromatid resolution during early stages of mitosis. Couples DNA replication to sister chromatid cohesion. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Gene Name
WAPAL FOE KIAA0261 WAPL
Protein name
Wings apart-like protein homolog (Friend of EBNA2 protein)
Human protein sequence Database
Q7Z5K2
Mouse protein sequence database
Q65Z40
Rat protein sequence database
Cellular localization
[Isoform 2]: Nucleus.; Nucleus. Chromosome. Cytoplasm. Associates with chromatin through the cohesin complex during interphase. Released in the cytoplasm from nuclear envelope breakdown until anaphase, it reaccumulates in nucleus at telophase.
Tissue expression
Isoform 1 is highly expressed in uterine cervix tumor. Isoform 2 is widely expressed with a high level in skeletal muscle and heart.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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