Molecular weight (DA)
51kD
Immunogen
Synthesized peptide derived from human MIDN
Specificity
This antibody detects endogenous levels of MIDN at Human, Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.
Protein name
Midnolin (Midbrain nucleolar protein)
Human protein sequence Database
Q504T8
Mouse protein sequence database
Q3TPJ7
Rat protein sequence database
Cellular localization
Nucleus, nucleolus . Nucleus . Cytoplasm, cytosol . Detected in the nucleus and nucleolus with no expression in the cytoplasm (By similarity). However, a later study finds expression in the nucleus and cytoplasm with no expression in the nucleolus (PubMed:24187134). .
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)