Molecular weight (DA)
6kD
Immunogen
Synthesized peptide derived from human Noxa
Specificity
This antibody detects endogenous levels of Noxa at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Protein name
Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)
Human protein sequence Database
Q13794
Mouse protein sequence database
Q9JM54
Rat protein sequence database
Q5U777
Cellular localization
Mitochondrion .
Tissue expression
Highly expressed in adult T-cell leukemia cell line.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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