Molecular weight (DA)
92kD
Immunogen
Synthesized peptide derived from human ATP6V0A1
Specificity
This antibody detects endogenous levels of ATP6V0A1 at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Function
Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity).
Gene Name
ATP6V0A1 ATP6N1 ATP6N1A VPP1
Protein name
V-type proton ATPase 116 kDa subunit a isoform 1 (V-ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116)
Human protein sequence Database
Q93050
Mouse protein sequence database
Q9Z1G4
Rat protein sequence database
P25286
Cellular localization
Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV. .
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
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