Molecular weight (DA)
83kD
Immunogen
Synthesized peptide derived from Nup88 . at AA range: 330-410
Specificity
Nup88 Polyclonal Antibody detects endogenous levels of Nup88 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasias. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016],
Function
function:Essential component of nuclear pore complex.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,subunit:Interacts with NUP214/CAN.,tissue specificity:Ubiquitous.,
Protein name
Nuclear pore complex protein Nup88
Other name
NUP88; Nuclear pore complex protein Nup88; 88 kDa nucleoporin; Nucleoporin Nup88
Fields
>>Nucleocytoplasmic transport;>>Amyotrophic lateral sclerosis
Human protein sequence Database
Q99567
Mouse protein sequence database
Q8CEC0
Rat protein sequence database
Cellular localization
Nucleus, nuclear pore complex .
Tissue expression
Ubiquitous.
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