Immunogen
Purified recombinant fragment of human GATA-3 expressed in E. Coli.
Specificity
GATA-3 Monoclonal Antibody detects endogenous levels of GATA-3 protein.
Formulation
Ascitic fluid containing 0.03% sodium azide,0.5% BSA, 50%glycerol.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/200 - 1/1000. ELISA: 1/10000.. IF 1:50-200
Purification process (Immunogen)
Affinity purification
Background
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009],
Function
disease:Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.,function:Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.,similarity:Contains 2 GATA-type zinc fingers.,tissue specificity:T-cells and endothelial cells.,
Protein name
Trans-acting T-cell-specific transcription factor GATA-3
Other name
GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3
Fields
>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Parathyroid hormone synthesis, secretion and action;>>Inflammatory bowel disease
Human protein sequence Database
P23771
Mouse protein sequence database
P23772
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
T-cells and endothelial cells.
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