Immunogen
Purified recombinant human TFIIH p62 (N-terminus) protein fragments expressed in E.coli.
Specificity
TFIIH p62 Monoclonal Antibody detects endogenous levels of TFIIH p62 protein.
Formulation
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
Dilution rate
Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
Purification process (Immunogen)
Affinity purification
Background
function:Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.,PTM:Phosphorylated.,similarity:Contains 2 BSD domains.,subunit:One of the six subunits forming the core-TFIIH basal transcription factor. Interacts with PUF60.,
Function
function:Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.,PTM:Phosphorylated.,similarity:Contains 2 BSD domains.,subunit:One of the six subunits forming the core-TFIIH basal transcription factor. Interacts with PUF60.,
Protein name
General transcription factor IIH subunit 1
Other name
GTF2H1; BTF2; General transcription factor IIH subunit 1; Basic transcription factor 2 62 kDa subunit; BTF2 p62; General transcription factor IIH polypeptide 1; TFIIH basal transcription factor complex p62 subunit
Fields
>>Basal transcription factors;>>Nucleotide excision repair;>>Viral carcinogenesis
Human protein sequence Database
P32780
Mouse protein sequence database
Q9DBA9
Rat protein sequence database
Cellular localization
Nucleus.
Tissue expression
Liver,Lung,
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