Molecular weight (DA)
22kD
Immunogen
The antiserum was produced against synthesized peptide derived from human BCL7A. AA range:21-70
Specificity
Bcl-7a Polyclonal Antibody detects endogenous levels of Bcl-7a protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Function
disease:Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8;14;12)(q24.1;q32.3;q24.1) with MYC and with immunoglobulin gene regions.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the BCL7 family.,
Protein name
B-cell CLL/lymphoma 7 protein family member A
Other name
BCL7A; B-cell CLL/lymphoma 7 protein family member A
Human protein sequence Database
Q4VC05
Mouse protein sequence database
Q9CXE2
Rat protein sequence database
Tissue expression
Brain,Thalamus,
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