Molecular weight (DA)
77kD
Immunogen
Synthesized peptide derived from human protein . at AA range: 480-560
Specificity
ACOX3 Polyclonal Antibody detects endogenous levels of protein.
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Dilution rate
WB 1:500-2000 ELISA 1:5000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).,cofactor:FAD.,function:Oxidizes the CoA-esters of 2-methyl-branched fatty acids.,pathway:Lipid metabolism; peroxisomal fatty acid beta-oxidation.,similarity:Belongs to the acyl-CoA oxidase family.,
Gene Name
ACOX3 BRCOX PRCOX
Protein name
Peroxisomal acyl-coenzyme A oxidase 3 (EC 1.3.3.6) (Branched-chain acyl-CoA oxidase) (BRCACox) (Pristanoyl-CoA oxidase)
Fields
>>Fatty acid degradation;>>beta-Alanine metabolism;>>alpha-Linolenic acid metabolism;>>Propanoate metabolism;>>Biosynthesis of unsaturated fatty acids;>>Metabolic pathways;>>Carbon metabolism;>>Fatty acid metabolism;>>PPAR signaling pathway;>>cAMP signaling pathway;>>Peroxisome;>>Alcoholic liver disease
Human protein sequence Database
O15254
Mouse protein sequence database
Q9EPL9
Rat protein sequence database
Q63448
Cellular localization
Peroxisome .
Tissue expression
Liver,Uterus,
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