Immunogen
The antiserum was produced against synthesized peptide derived from human CDK5RAP2. AA range:251-300
Specificity
CDK5 Activator-binding C48 Polyclonal Antibody detects endogenous levels of CDK5 Activator-binding C48 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013],
Function
disease:Defects in CDK5RAP2 are the cause of primary microcephaly autosomal recessive type 3 (MCPH3) [MIM:604804]. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits.,function:Potential regulator of CDK5 activity via its interaction with CDK5R1.,miscellaneous:The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.,PTM:Phosphorylated in vitro by CDK5.,sequence caution:Translated as Gln.,subunit:Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK
Protein name
CDK5 regulatory subunit-associated protein 2
Abbreviation
CDK5 Activator-binding C48
Other name
CDK5RAP2; CEP215; KIAA1633; CDK5 regulatory subunit-associated protein 2; CDK5 activator-binding protein C48; Centrosome-associated protein 215
Human protein sequence Database
Q96SN8
Mouse protein sequence database
Q8K389
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Golgi apparatus . Cytoplasm . Cytoplasm, cytoskeleton . Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localizes to microtubule plus ends in the presence of EB1/MAPRE1. Localization to centrosomes versus Golgi apparatus may be cell type-dependent. For instance, in SK-BR-3 and HEK293F cells, localizes to centrosomes but not to the Golgi apparatus (PubMed:29162697). .
Tissue expression
Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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