Immunogen
The antiserum was produced against synthesized peptide derived from human CHRC1. AA range:81-130
Specificity
CHRAC15 Polyclonal Antibody detects endogenous levels of CHRAC15 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC: 1/100 - 1/300. ELISA: 1/5000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
CHRAC1 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004],
Function
function:Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1.,subunit:Interacts with POLE3. Together with POLE3, ACF1 and ISWI/SNF2H proteins, it forms the ISWI chromatin-remodeling complex, CHRAC.,tissue specificity:Expressed in all tissues tested, including, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.,
Protein name
Chromatin accessibility complex protein 1
Other name
CHRAC1; CHRAC15; Chromatin accessibility complex protein 1; CHRAC-1; Chromatin accessibility complex 15 kDa protein; CHRAC-15; HuCHRAC15; DNA polymerase epsilon subunit p15
Human protein sequence Database
Q9NRG0
Mouse protein sequence database
Q9JKP8
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
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