Molecular weight (DA)
17kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MtSSB. AA range:99-148
Specificity
SSBP1 Polyclonal Antibody detects endogenous levels of SSBP1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010],
Function
function:This protein binds preferentially and cooperatively to ss-DNA. Probably involved in mitochondrial DNA replication.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 SSB domain.,subunit:Homotetramer.,
Protein name
Single-stranded DNA-binding protein mitochondrial
Other name
SSBP1; SSBP; Single-stranded DNA-binding protein; mitochondrial; Mt-SSB; MtSSB; PWP1-interacting protein 17
Fields
>>DNA replication;>>Mismatch repair;>>Homologous recombination
Human protein sequence Database
Q04837
Mouse protein sequence database
Q9CYR0
Rat protein sequence database
P28042
Cellular localization
Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid .
Tissue expression
Expressed in retinal ganglion cells, photoreceptors, pigmented epithelium and fibroblasts (at protein level).
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