Molecular weight (DA)
20 52kD
Immunogen
Synthesized peptide derived from human PPGB (20k, Cleaved-Met327)
Specificity
This antibody detects endogenous levels of Human,Mouse PPGB (20k, Cleaved-Met327, protein was cleaved amino acid sequence between 326-327 )
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
catalytic activity:Release of a C-terminal amino acid with broad specificity.,disease:Defects in CTSA are the cause of galactosialidosis [MIM:256540]. It is an autosomal recessive disease.,function:Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins.,similarity:Belongs to the peptidase S10 family.,subunit:Heterodimer of a 32 kDa chain and a 20 kDa chain; disulfide-linked.,
Function
proteolysis, intracellular protein transport, protein localization, protein transport, cellular protein localization,establishment of protein localization, intracellular transport, cellular macromolecule localization,
Protein name
PPGB (20k, Cleaved-Met327)
Other name
Lysosomal protective protein (EC 3.4.16.5;Carboxypeptidase C;Carboxypeptidase L;Cathepsin A;Protective protein cathepsin A;PPCA;Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain]
Fields
>>Lysosome;>>Renin-angiotensin system
Human protein sequence Database
P10619
Mouse protein sequence database
P16675
Rat protein sequence database
Cellular localization
Lysosome.
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