Welcome to Nanjing Byabscience    HOTLINE: 800-880-8748 |
Location: Home > Products > Primary Antibodies > Polyclonal antibody

CYP2A13 Polyclonal Antibody

Polyclonal antibody

Specification

BYab-02575

  • 50UL $180 100UL $255
  • Delivery: In Stock

Product introduction Experimental scheme Citation Related products

Product introduction>

Host
Reactiveness
Use
Molecular weight (DA)
56kD
Immunogen
The antiserum was produced against synthesized peptide derived from human Cytochrome P450 2A13. AA range:311-360
Specificity
CYP2A13 Polyclonal Antibody detects endogenous levels of CYP2A13 protein.
Source
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Background
cytochrome P450 family 2 subfamily A member 13(CYP2A13) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008],
Function
catalytic activity:RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.,cofactor:Heme group.,function:Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.,online information:CYP2A13 alleles,polymorphism:The frequencies of the Cys-257 allele in white, black, Hispanic, and Asian individuals are 1.9%, 14.4%, 5.8%, and 7.7%, respectively. The Cys-257 variant is 37 to 56% less active than the wild-type Arg-257 protein toward all substrates tested.,similarity:Belongs to the cytochrome P450 family.,tissue specificity:Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but n
Gene Name
CYP2A13
Protein name
Cytochrome P450 2A13
Abbreviation
CYP2A13
Other name
CYP2A13; Cytochrome P450 2A13; CYPIIA13
Fields
>>Metabolism of xenobiotics by cytochrome P450;>>Chemical carcinogenesis - DNA adducts
Human gene ID
1553
Human protein sequence Database
Q16696
Mouse gene ID
Mouse protein sequence database
Rat gene ID
Rat protein sequence database
Cellular localization
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue expression
Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle.
Storage
-20°C/1 year

Experimental scheme>

Procedure

Citation(0)>

Related products>

成功添加到购物车

查看购物车 继续购物

CYP2A13 Polyclonal Antibody

亮暗模式切换
X

Online
Service

Online Service
08:30 - 17:30

service hotline

Service
Hotline

Customer service hotline

800-880-8748
Customer service hotline

扫码

Scan
Wechat

微信二维码 Scan wechat
返回顶部 TOP