Molecular weight (DA)
29kD
Immunogen
The antiserum was produced against synthesized peptide derived from human MARCH3. AA range:111-160
Specificity
MARCH3 Polyclonal Antibody detects endogenous levels of 40605 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/40000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013],
Function
domain:The RING-CH-type zinc finger domain is required for E3 ligase activity.,function:E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 RING-CH-type zinc finger.,subunit:Interacts with MARCH2 and STX6.,
Protein name
E3 ubiquitin-protein ligase MARCH3
Other name
MARCH3; RNF173; E3 ubiquitin-protein ligase MARCH3; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; MARCH-III; RING finger protein 173
Human protein sequence Database
Q86UD3
Mouse protein sequence database
Q8BRX9
Rat protein sequence database
Q5XIE5
Cellular localization
Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein .
Tissue expression
Brain,Thalamus,
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